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Beside detrimental effects of the apoE4 isoform on a number of factors that are linked to AD pathogenesis such as neurite outgrowth, cytoskeletal stabilization, A clearance (for review see ref

However, our natural levels of glutathione can fluctuate

201 however, disruption of the ubiquitin system does not affect oxidized protein degradation, 195 suggesting that the 20S ubiquitin/ATP- independent proteasome is responsible for protein degradation during oxidative stress

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