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Ethics declarations Competing interests T.M., J.H.E., J.B.H., D.P.C., M.B.F.G., M.T.-C., T.W.S

Medable's mobile eClinical platform and Mahalo Health's participant engagement application are representative deployments, each combining validated ePRO data capture with push notification reminders, appointment management interfaces, and direct communication channels to site coordinators reducing the coordination overhead that traditionally required telephone or email outreach between participants and study teams

However, when Spearman's rank correlation analysis was performed, no significant correlation (P=0.32) was found between the estrogen levels in the blood and the GSH expression in the RBC (Fig

doi: 10.1016/j.jcmgh.2019.08.004 49 BhatPLeggattGWaterhouseNFrazerIH