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In another research, mangiferin, a naturally occurring polyphenolic compound and one of the most potent bioactive xanthonoid molecules identified to date was found to mitigate CIS-induced toxicity both in vitro and in vivo

P53-deficient mice and mice systematically receiving the p53 inhibitor pifithrin are less susceptible to cuprizone-induced demyelination and show an enhanced oligodendrocytic survival (Li et al., 2008)

Research suggests a slow build across the activation and consolidation phases rather than an overnight effect

PMID: 128 GomezALuckeyDYeomanCMariettaEVBerg MillerMEMurrayJAet al