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doi: 10.5152/eurjrheum.2017.17025

This signaling promotes mitochondrial biogenesis and fatty acid oxidation, and indirectly facilitates a shift toward an anti-inflammatory M2 macrophage phenotype (34)

Evidence remains largely preclinical, but findings indicate possible benefits in reducing inflammation and aiding recovery in digestive tissues, especially in conditions involving ulcers or irritation

They need the basic background

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks ( In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans