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Next, to mitigate the transplantation-associated inflammation and physical damage associated with the transplantation procedure, immune-tolerizing gene-cell strategies using CRISPR knock-ins, such as the transplantation of DA cells engineered to express ligands that attenuate T-cell/NK/complement activity, could enhance both survival and functional integration while reducing chronic immune responses

doi: 10.1016/j.cbi.2023.110407

Neuronal and glial cell death in the necrotic region is linked to impaired blood flow and the disruption of the blood-brain barrier (BBB) integrity, potentially resulting in additional intracerebral haemorrhage and edema due to vascular leakage (Corps, Roth and McGavern, 2015)

Glycine plays important role in anti-bacterial activities and inhibition of tumor growth as a precursor of nucleotide synthesis in cell proliferation

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