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Insights on the Use of -Lipoic Acid for Therapeutic Purposes

Three studies totaling 578 patients with cancer investigated the effect of ALC in preventing chemotherapy-induced neuropathy, but no positive effect was detected

It must be highlighted that rat skeletal muscle TC increases ~ 5070% following 4 weeks of LC supplementation [33, 34], whereas comparable elevation has never been observed in human studies, even after 24 weeks of supplementation [5, 7]

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Direct measurements of carnitine in skeletal muscles failed to show any elevation in the muscle carnitine concentration following 14 days of 4 g/day [21], or 6 g/day [22] LC ingestion