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E: Erastin ELISA: Enzyme-linked immunosorbent assay GAPDH: Glyceraldehyde-3-phosphate dehydrogenase GPX4: Glutathione peroxidase 4 GSH: Glutathione H&E: Hematoxylin and eosin 4-HNE: 4-hydroxynonenal HSGE cells: Human salivary gland epithelial cells HO-1: Heme oxygenase-1 IL-1: Interleukin-1 IL-6: Interleukin-6 IF: Immunofluorescence IFN-: Interferon- IHC: Immunohistochemistry Ly: Lymphocyte infiltration Keap1: Kelch-like ECH-associated protein 1 MDA: Malondialdehyde MHC II: Major histocompatibility complex class II MLT: Melatonin NFIL3: Nuclear factor interleukin-3-regulated factor NRF2: Nuclear factor erythroid 2-related factor 2 NF-B: Nuclear factor-kappa B pSS: Primary Sjgrens syndrome PVDF: Polyvinylidene fluoride ROS: Reactive oxygen species RTqPCR: Reverse transcription quantitative polymerase chain reaction ROR: Orphan nuclear receptor retinoic acid-related receptor ROR-t: Orphan nuclear receptor retinoic acid-related receptor-t SPF: Specific pathogen-free SG: Salivary gland SGECs: Salivary gland epithelial cells System Xc : Cystine-glutamate antiporter system Xc TEM: Transmission electron microscopy TNF-: Tumor necrosis factor TLRs: Toll-like receptors References Mathews SA, Kurien BT, Scofield RH

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