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Several of the changes observed in connective tissue are thought to reflect variations in the levels of MMPs, the enzymes involved in regulating and maintaining the extracellular matrix that degrade extracellular matrix molecules, proteoglycans, elastin, and different types of collagens [109]

Hiddemann W, Buechner T, Andreeff M , Woermann B, Clarkson BD
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To assess the effects of NMN supplementation in a mouse model of early-stage ALD, various techniques were used, including WB, PCR, and H&E staining