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Since the bond formed between heme and carbon monoxide is less dissociable than the hemeoxygen bond, severe disruption of normal oxygen transport can occur

Second, as mentioned above, c-Met inhibitors which target the interaction between HGF and c-Met may lose efficacy owing to cell attachment (Wang et al., 2001), gene amplification of c-Met, DCP binding to c-Met (Suzuki et al., 2005), gene mutation in the c-Met activation loop (Okuma and Kondo, 2016) and crosstalk with other membrane receptors (Steinway et al., 2015)

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