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Description
Scientists use standard pain scales and movement tests to measure the changes

Science 321(5891):952 Takahama U (2004) Oxidation of vacuolar and apoplastic phenolic substrates by peroxidase: physiological significance of the oxidation reactions

Although the exact cause is still unknown, several factors are believed to contribute to its development

Int J Mol Sci (2019) 20:4871

Kojic acid is most effective for hyperpigmentation-related darkening, not for issues like dehydration or irritation