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Its also worth calling out that other conditions can cause similar symptoms: Osteoarthritis

In the published literature it is most often discussed in the context of tissue and gastrointestinal work, where it has been studied in in-vitro and animal models and described in relation to connective-tissue and cytoprotection research
Nunbhakdi-Craig, V

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DNA methylation of the BDNF gene and its relevance to psychiatric disorders