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Tian S, et al

Ausserhalb der Reichweite von Kindern aufbewahren

We reasoned that a rare variant with potential functional significance observed in two or more subjects was more likely to impair TMA metabolism

One of the physiological substrates of this transporter is acetylcholine, underlying a key role in the non-neuronal cholinergic system in both physiological and pathological conditions, as testified by the occurrence of a natural mutation of OCTN1 in inflammatory conditions such as Crohns Disease (Pochini et al., 2019)

Reducing the levels of Akt activation by PDK1 knock-in mutation protects neuronal cultures against synthetic amyloid-beta peptides