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Among the Supplements Creatine Shows the Most Promise as a Neuroprotective Agent Coenzyme Q10 (CoQ10), also known as ubiquinone, is a promising agent for neuroprotection in PD and other neurodegenerative diseases because of its role in the mitochondrial electron transport chain (METC) and as an antioxidant (Beal and Shults, 2004), suppressing intra-mitochondrial and intra-nuclear biosynthesis of 8-OH-2dG, inhibiting translocation of caspase-3, attenuating -synuclein expression, and blocking intra-mitochondrial accumulation of metal ions (Ebadi et al., 2004)

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