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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

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Furthermore, some in vitro experiments have also found that AOD 9604 can affect the expression of related genes in adipocytes, such as promoting the expression of genes related to axunge breakdown and inhibiting the expression of genes related to axunge synthesis, thereby regulating axunge metabolism at the genetic level

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial