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Over the following decades, Pickart (who passed away in 2023 at age 85) and collaborators documented GHK-Cu's effects on wound healing, collagen production, hair growth, nerve outgrowth, and inflammation, building a substantial body of evidence that the peptide functions as a systemic tissue repair signal rather than having effects limited to any single tissue type

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PPARalpha/gamma agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats

Unlike growth factors requiring carriers for delivery, BPC-157 works effectively on its own
Additionally, vivo studies have found it helps lower blood pressure, reducing strain on the heart and minimizing cardiovascular risks
