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If you dont have enough B12, you can end up developing a certain kind of anemia known as megaloblastic anemia

It is a specific 16-amino acid fragment of human growth hormone, corresponding to the region between amino acids 176 and 191

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But, if either substances are pushed too quickly the resulting damage to the tissue can cause a nasty charley horse like pain that can persist for hours or days

There are practical reasons too: B can be unstable if mixed with certain other vitamins in solution, and dosing schedules for B deficiency (pernicious anemia, for instance) may differ