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Slo los anlisis de subgrupos encontraron beneficios significativos de la citicolina en pacientes mayores de 70 aos, en aquellos con accidentes cerebrovasculares moderados en lugar de graves y en aquellos no tratados con activador del plasmingeno tisular recombinante (rtPA

Therefore, the loss of estrogen production may explain the more prominent A neuropathology observed in women but also the switch toward an A-driven prooxidant state, which underlies AD development

However, this study has several limitations

It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation