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It involves a diverse array of ROS species generated from multiple sources with distinct reactivities and temporal patterns throughout ischemia and reperfusion
This is a credibility limitation, not a safety verdict
In oxidative stress conditions, multiple cysteine residues of KEAP1 are oxidized by ROS, causing structural changes followed by Zn release and complex dissociation [6,30]
On the one hand, these observations might be explained by the fact that an estrogen drop is required for the onset of ovulation 88 , and several flavoproteins (proteins using FMN and FAD as coenzyme) assist estrogen degradation by cytochrome P450 51,89 as they balance electrons from these reactions
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