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287,288 The generation of ROS and the imbalance of the antioxidant system further damage mitochondrial DNA, lipids, and proteins, aggravating mitochondrial dysfunction and cellular apoptosis

In cell cultures and animal models of neurodegenerative diseases SS-31 (MTP-131, Elamipretide, Bendavia) upregulated mRNAs for ETC complexes I, IV, and V, for PGC-1 and TFAM, and improved mitochondrial dynamics by upregulating mitochondrial fusion proteins and downregulating proteins regulating fission

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In human history, herbal formulas and their extracts have been used in the treatment of human diseases due to their high efficacy and low toxicity

BPC-157 has been studied for its potential interaction with nitric oxide synthase activity and vascular endothelial growth factor (VEGF) signaling, which regulate tissue organization and endothelial function through gene expression modulation rather than direct receptor activation