semaglutide wears off end of week Can You Skip a Wegovy (Semaglutide)? Semaglutide Duration & Wear-Off Timeline

Gastrointestinal Issues : Conditions such as diverticulitis (inflammation or infection of small pouches in the colon), constipation, trapped gas, or irritable bowel syndrome (IBS) can all result in sharp or recurrent pain in the lower left abdomen

JAMA points out that "these adverse events, although rare, must be considered by patients who are thinking about using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes" [20]

Yes, and its strongly recommended

2018;42:S42

This can also change the texture of skin, which as a result, can make cellulite more visible