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Despite the strength in the large cumulative sample size and compilation of data from the statistically robust design of RCTs, one of the major limitations of meta-analysis studies for retinopathy is the lack of standardization in reporting and detecting retinopathy across the included trials

It's worth noting that when GLP-1 receptor agonists are used alongside insulin or sulfonylureas, there is an increased risk of hypoglycaemia, and dose adjustments of these medications may be required