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Off-Label Use: A Growing Concern GLP-1s approved for T2D are frequently used off-label for weight loss, raising concerns among both employers and health plans

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Kopp K

The new results suggest but dont prove that the weight-loss medications may be able to target the underlying source of cravings that affect the more than 48 million Americans with substance use disorders

These key factors can slow progress: metabolismhow fast your body burns calories at rest whether you dose as directed or skip doses lack of consistent lifestyle changes like diet and exercise stopping because of side effects age having a lower starting weight, BMI, or waist circumference The Bottom Line Both liraglutide and semaglutide help control blood sugar, support weight loss, and lower cardiovascular risk