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Regulatory activities, including Food and Drug Administration and European Medicines Agency actions Regulatory actions have evolved in response to emerging safety concerns

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Patients with a history of pancreatitis (inflammation of the pancreas) or those who have had thyroid cancer or a family history of medullary thyroid cancer should avoid semaglutide due to potential risks

Some patients may find injections uncomfortable or experience pain at the injection site, leading to decreased adherence to treatment

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