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Clinical decisions should always be based on the balance of benefits and risks for each patient, taking into account their complete medical history and current health status

Notably, alterations in cholinergic signaling, neuroinflammation involving microglial activation, and calcium dysregulation have emerged as relevant contributors to AD pathogenesis

While preclinical and mechanistic studies offer important insights, regulatory and clinical decision-making requires robust, patient-centered data derived from randomized trials

The emphasis is on the last of those

Lower net acquisition costs for GLP-1 medications would strengthen the economic case for maintaining or adding GLP-1 coverage for obesity