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The diabetes and obesity epidemics keep growing with each year of sedentary lifestyle and caloric excess in developing nations whose middle classes are expanding rapidly

J Clin Endocrinol Metab (1993) 77(5):128793.10.1210/jc.77.5.1287 36 StevenSHollingsworthKGSmallPKWoodcockSAPucciAAribasalaBet alCalorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in type 2 diabetes

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Longitudinal studies should investigate how these agents impact long-term health outcomes, such as the incidence of cardiovascular diseases and mortality

Insurance coverage varies widely, with some plans offering limited reimbursement options, further restricting patient access