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This is particularly relevant for the long-acting weekly formulations, where minor variations in absorption rate would have minimal impact on overall therapeutic effect

While some patients might lose a pound or two during the first weekoften a combination of decreased food intake and a reduction in water weight or inflammationsignificant, visible weight loss typically takes weeks to months to materialize

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Oral GLP-1 medications may be a reasonable option for: Patients early in their weight loss journey Patients with mild to moderate weight loss goals Patients who strongly prefer to avoid injections They may be less ideal for: Patients who have had bariatric surgery Patients needing significant weight loss Patients who have not responded to oral medications in the past The decision is not just about preference

Novo Nordisk last week said Wegovy cut the risk of heart attack, stroke or death by 57% versus Eli Lilly's weight loss injection Zepbound in a real-world comparison of the rival medicines in patients with obesity and cardiovascular diseases but not diabetes