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In addition, in the 14-month-old APP SWE /PS1 E9 mouse, inflammation was also markedly reduced and restorative effects were improved by liraglutide treatment [91]

Given the broad use of GLP-1 drugs, the scope of this MDL could reach tens of thousands of claims in 2025

Understanding how GLP-1 regulates inflammation (Figure 1) provides insights into the pleiotropic weight lossindependent benefits of GLP-1R agonism, potentially explaining its actions to reduce the severity of several chronic diseases marked by dysregulated immune function and inflammation

Liraglutide (LIRA) and semaglutide (SEMA) gained approval by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for weight reduction in obese individuals or people who are overweight with BMI 27 kg/m 2 and also experience at least one weight-associated comorbid situation (such as hypertension, dyslipidemia, prediabetes and OSA) combined to lifestyle modifications [71]

The blood pressure-lowering effect may be partly mediated by weight loss, though other mechanisms may also contribute