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NAC: A key source of cysteine that fuels glutathione synthesis and supports antioxidant defense.*

Therefore, NADPH may also play a role in promoting ferroptosis

Beneficial effect of CoQ10 supplementation was also observed in a case report and resulted in reduced oxidative stress markers, improved mitochondrial functions, and diminished clinical symptoms [46]

Possible explanations for how HRT could adversely affect MASLD development include adverse effects from the progesterone component of HRT (which is infrequently considered in existing studies), nonphysiologically high hepatic estrogen exposure from oral estrogens, and the inability to replicate the natural oscillatory patterns of hepatic estrogen exposure in the premenopausal state (10)